Vasculitis: current issues: IP93. Pathogenesis of Vasculitis
نویسندگان
چکیده
منابع مشابه
Pathogenesis of lung vasculitis.
Vasculitides that affect the lung represent a diverse group of diseases with various systemic clinical manifestations, and include microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis), Churg-Strauss syndrome (CSS), and anti-glomerular basement membrane (anti-GBM) disease (Goodpasture syndrome). The etiologies of these diseases remain largely un...
متن کاملPathogenesis of ANCA-associated vasculitis.
Antineutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitides (AAV) are a group of systemic vasculitis syndromes characterized by inflammation and necrosis of blood vessel walls. Genetic, epigenetic, and environmental factors contribute to the etiology and pathogenesis of AAV. On the basis of currently available clinical and experimental evidence, it is reasonable to believe that, in...
متن کاملRole in the Pathogenesis of Vasculitis
Antineutrophil cy to plas mic an ti bod ies (ANCA) are a het er o ge neous group of cir cu lat ing an ti bod ies di rected to ward the cy to plas mic con stit u ents of neutrophil gran ules and monocytes. ANCA were first de scribed in 1982 by Davies et al. in a few pa tients with seg men tal necrotizing glomerulone phritis (1,2). The im por tance of this ob ser va tion had not been rec og nized...
متن کاملThe evolving pathogenesis of systemic vasculitis.
The primary small vessel systemic vasculitides are disorders that target small blood vessels, inducing vessel wall inflammation and associated with development of antineutrophil cytoplasmic antibodies. Multiple organs are attacked including the lungs and kidneys. Increasing knowledge of pathogenesis suggests that the antibodies activate neutrophils inappropriately, leading to endothelial and va...
متن کاملThrombosis in vasculitis: from pathogenesis to treatment
In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected. Inflammation-induced thrombosis is by now considered a feature not only of autoimmune rheumatic diseases, but also of systemic vasculitides such as Behçet's syndrome, ANCA-associated vasculitis or giant cells ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2011
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/ker066